Xenotransplantation of Cultured Human Corneal Endothelial Cell Sheets
نویسندگان
چکیده
منابع مشابه
Cytotoxicity of ganciclovir on cultured human corneal endothelial cells.
BACKGROUND Intraocular cytomegalovirus (CMV) infections, including endotheliitis and retinitis, have been reported to threaten the host's vision. These infections have been treated with systemic or intravitreal GCV injection. Intracameral GCV injection can be an effective treatment option that avoids systemic side effects. The cytotoxic effect of ganciclovir (GCV) on cultured human corneal endo...
متن کاملCorneal Endothelial Tissue Bioengineering Using Cultured Human Corneal Endothelial Precursor Cells
The cornea is composed of a multilayered epithelium, Bowman's membrane, stroma, Descemet's membrane, and endothelium. The corneal endothelium (CE) is a single layer of hexagonal cells that separates the corneal stroma from the aqueous humor of the anterior chamber. Transparency of the cornea is maintained by regulation of stromal hydration through the barrier and pump functions of the CE, and c...
متن کاملSuccessful transplantation of in vitro expanded human corneal endothelial precursors to corneal endothelial surface using a nanocomposite sheets.
BACKGROUND Though the transplantation of in vitro expanded human corneal endothelial precursors in animal models of endothelial damage by injecting into the anterior chamber has been reported, the practical difficulties of accomplishing such procedure in human patients have been a hurdle to clinical translation. Here we report the successful transplantation of in vitro expanded human corneal pr...
متن کاملKaryotype changes in cultured human corneal endothelial cells
PURPOSE To examine karyotype changes in cultured human corneal endothelial cells (HCECs). METHODS HCECs with Descemet's membrane were removed from 20 donors of various ages (range, 2-77 years; average, 43.7+/-26.4 years) and cultured on dishes coated with extracellular matrix produced by bovine corneal endothelial cells (BCECs). Karyotype changes were examined by G-band karyotyping of HCECs a...
متن کاملHeterologous corneal endothelial cell transplantation--human corneal endothelial cell transplantation in Lewis rats.
A heterologous corneal endothelial transplantation was attempted using human endothelial cells and a Lewis rat penetrating keratoplasty model. Cultured human endothelial cells were seeded to a Lewis rat cornea, which was denuded of its endothelium. When grafted into the syngeneic Lewis rat, the graft remained clear for at least five days, and then became opaque and edematous because of immune r...
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ژورنال
عنوان ژورنال: Journal of the Korean Ophthalmological Society
سال: 2018
ISSN: 0378-6471,2092-9374
DOI: 10.3341/jkos.2018.59.6.497